How does Grenade .50 Calibre work? The ingredients in Grenade .50 Calibre have been shown in clinical research studies to support exercise performance, increased use of fat for fuel and increased nitric oxide levels and therefore blood flow and incredible muscle pumps. Unlike the majority of products on the market, Grenade .50 Calibre uses research-supported dosages of active ingredients. Many products use 'proprietary blends' to hide the fact that they only use a 'dusting' of certain ingredients to make the label look good. Others just use very low dosages of ingredients in the knowledge that many consumers won't be aware of the effective amounts. .50 Calibre only contains scientifically-supported dosages of active ingredients so that you really 'feel' the results in the gym and see them in the mirror!