Adaptil has been scientifically proven by research published in numerous scientific journals to be an effective and safe tool to relieve stress related behaviours in dogs and puppies of all ages. It is odourless and, non-sedative and has no effect on humans or other animals. When the vial in your diffuser runs out, simply purchase another 48ml refill and slot it into your existing diffuser. The Adaptil/DAP diffuser (Dog Appeasing Pheromone) from CEVA Animal Health is a plug-in diffuser that releases pheromones into your home, that although odourless to you will have an amazing effect on calming your dog at times of stress. Adaptil is useful in all sorts of stressful situations, and helps eliminate undesirable activity, such as chewing, barking and urinating in the house.